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Monday, January 4, 2010

ScienceDaily Health Headlines -- for Monday, January 4, 2010

ScienceDaily Health Headlines

for Monday, January 4, 2010

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Psoriasis: Effects don’t always stop with the skin (January 4, 2010) -- Psoriasis, a chronic disease that causes red, raised patches of skin, is increasingly seen as a systemic disease with links to arthritis and cardiovascular disease. ... > full story

How ubiquitin chains are added to cell-cycle proteins: May lead to targeted cancer therapies (January 4, 2010) -- Researchers have been able to view in detail, and for the first time, the previously mysterious process by which long chains of a protein called ubiquitin are added by enzymes called ubiquitin ligases to proteins that control the cell cycle. Ubiquitin chains tag target proteins for destruction by protein-degrading complexes in the cell. ... > full story

Osteopontin contributes to allergic contact dermatitis (January 4, 2010) -- Researchers in Germany have discovered that osteopontin (OPN) contributes to allergic contact dermatitis. ... > full story

Increased risk of death, stroke in postmenopausal women taking antidepressants, study finds (January 4, 2010) -- Women participating in the Women's Health Initiative study who reported taking an antidepressant drug had a small but statistically significant increase in the risk of stroke and of death compared with participants not taking antidepressants. The authors of the study note that their findings are not conclusive but may signify a need for additional attention to patients' cardiovascular risk factors. ... > full story

Multitasking may be Achilles heel for hepatitis C (January 4, 2010) -- Despite its tiny genome, the hepatitis C virus packs a mean punch. The virus is a microcosm of efficiency, and each of its amino acids plays multiple roles in its survival and ability to sidestep attack. But new research suggests that this fancy footwork and multitasking could be the key to bringing down the virus. The work, which focuses on a once-ignored protein, provides insights on how drug therapy for sufferers of the disease might be improved. ... > full story

Scientists visualize how a vital hepatitis C virus protein moves along its nucleic acid substrate (January 4, 2010) -- By taking three conformational snapshots of a hepatitis C virus motor protein in association with its substrate, researchers have provided the first structural explanation of how a representative superfamily 2 helicase moves unidirectionally along nucleic acid, suggesting new ways that drug designers could block virus replication. ... > full story

Inflammatory mediator regulates diarrhea in inflammatory bowel disease (January 4, 2010) -- Researchers have discovered that activation of NF-kappaB, an inflammatory mediator, results in diarrhea in inflammatory bowel disease (IBD). ... > full story

Three new alkaloids found in winter snowdrop plants (January 4, 2010) -- Scientists have identified 17 bioactive compounds in winter snowdrops, the earliest flowering plants in Europe. Out of the alkaloids identified, three are new to science and belong to a group with potential applications in treating malaria and Alzheimer's disease. ... > full story

Pharmacists improve care of diabetics while cutting costs, research shows (January 4, 2010) -- The role of pharmacists hasn't received much attention in the debate on the cost of health care. But national and regional studies show that when pharmacists directly participate in patient care, they significantly reduce treatment costs and improve outcomes. ... > full story

Mutant gene lessens devastation of flesh-eating bacteria (January 3, 2010) -- Scientists recently discovered a simple gene mutation that decreases the chance people will get a flesh-eating disease called necrotizing fasciitis. Further, they proved that inactivating this section of the gene lessens the devastating disease in humans. ... > full story

Carbon nanotubes show promise for high-speed genetic sequencing (January 3, 2010) -- Scientists have demonstrated the potential of a new DNA sequencing method in which a single-stranded ribbon of DNA is threaded through a carbon nanotube. ... > full story

Alzheimer's: How amyloid beta reduces plasticity related to synaptic signaling (January 3, 2010) -- The early stages of Alzheimer's disease are thought to occur at the synapse, since synapse loss is associated with memory dysfunction. Evidence suggests that amyloid beta plays an important role in early synaptic failure, but little has been understood about amyloid beta's effect on the plasticity of dendritic spines. ... > full story

Two proteins act as molecular tailors in DNA repair (January 3, 2010) -- Every day tiny segments of our DNA are chipped or fragmented or get stuck together when they should really be pulled apart. But what our genome necessarily lacks in stability it makes up for with a phalanx of guards that monitor and repair the damage. ... > full story

Changing Behavior Helps Patients Take Medication As Prescribed (January 3, 2010) -- Researchers found that applying behavior changing strategies, such as using pill boxes or reducing the number of daily doses, can improve patients' abilities to take their medications as required. ... > full story

'Lifeless' prions capable of evolutionary change and adaptation (January 3, 2010) -- Scientists have determined for the first time that prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, are capable of Darwinian evolution. ... > full story

Unusual protein modification involved in muscular dystrophy, cancer (January 3, 2010) -- With the discovery of a new type of chemical modification on an important muscle protein, a new study improves understanding of certain muscular dystrophies and could potentially lead to new treatments for the conditions. ... > full story

Physiologic factors linked to image quality of multidetector computed tomography scans (January 3, 2010) -- The image quality of multidetector computed tomography scans, used for the noninvasive detection of coronary artery disease, can be significantly affected by patient characteristics such as ethnicity, body mass index and heart rate, according to a new study. ... > full story

Telephone Depression Program Offers Benefits At A Moderate Cost (January 3, 2010) -- Patients who participate in a structured telephone program to manage their depression appear to experience significant benefits and only a moderate increase in health care costs when compared with those who receive usual care, according to a new report. ... > full story

Scientists identify DNA that regulates antibody production (January 3, 2010) -- Performance enhancers are the currency of a competitive society. But there's one that we have always had: For millions of years, segments of our DNA have improved the performance of our genome, revving up protein production at those times we need it most. New research now show that these genome enhancers regulate how our bodies make germ-fighting antibodies, molecules that keep savvy viruses and bacteria at bay. ... > full story

Small changes in protein chemistry play large role in Huntington's disease (January 3, 2010) -- Investigators studying the toxic protein at the root of Huntington's disease have found that small biochemical changes to the protein have a large effect on its toxicity. These changes could be exploited or mimicked to develop a drug treatment for Huntington's. ... > full story

Molecular anchor links the two inheritable diseases Fanconi anemia and Bloom's syndrome (January 3, 2010) -- A new study establishes a molecular link that bridges two rare inherited disorders and explains why these diseases result in genetic instability. The research may lead to a better understanding of the complex mechanisms that enable cells to repair damaged DNA. ... > full story

Fungus contaminant in corn, peanuts, soybeans: Chlorophyll effective against aflatoxin (January 3, 2010) -- A new study has found that chlorophyll and its derivative chlorophyllin are effective in limiting the absorption of aflatoxin in humans. Aflatoxin is produced by a fungus that is a contaminant of grains including corn, peanuts and soybeans; it is known to cause liver cancer -- and can work in concert with other health concerns, such as hepatitis. ... > full story

The Skinny On 'Lean' Education (January 3, 2010) -- Educators should learn from the "Just-In-Time" and "Lean" production techniques used by the automotive industry if they are to add value to the student experience as quickly and effectively as possible. ... > full story

High fat diet increases inflammation in the mouse colon (January 2, 2010) -- Colorectal cancer, the third most common type of cancer worldwide, has been linked to an increased prevalence of the Western diet: one high in fat and low in fiber, vitamin D and calcium. Now, scientists have shown what happens to colon tissue when mice are fed such a diet: an inflammatory response that could be the trigger for carcinogenic processes. ... > full story

Imaging study shows HIV particles assembling around genome of infected cell (January 2, 2010) -- HIV is a wily and lethal replicator. In less than 25 years, it's killed more than 25 million people. Scientists are exploring exactly how this virus reproduces because they would like to find a way to abort the process. Now, just two years after scientists witnessed the birth of a single HIV particle in real time, the same team has zoomed in for a closer look at how the virus packages its genetic material as it assembles beneath the surface of an infected cell. ... > full story

Use of telemedicine for ICU patients not linked with improvement in survival (January 2, 2010) -- Remote monitoring of patients in intensive care units (ICUs) was not associated with an overall improvement in the risk of death or length of stay in the ICU or hospital, according to a new study. ... > full story

Earlier bedtimes may help protect adolescents against depression and suicidal thoughts (January 2, 2010) -- New research finds that adolescents with bedtimes that were set earlier by parents were significantly less likely to suffer from depression and to think about committing suicide, suggesting that earlier bedtimes could have a protective effect by lengthening sleep duration and increasing the likelihood of getting enough sleep. ... > full story

Elusive protein points to mechanism behind hearing loss (January 2, 2010) -- A serendipitous discovery of deaf zebra fish larvae has helped narrow down the function of an elusive protein necessary for hearing and balance. The work suggests that hearing loss may arise from a faulty pathway that translates sound waves into electrical impulses the brain can understand. ... > full story

Will higher global temperatures make it easier for viruses to jump species? (January 2, 2010) -- Scientists soon will begin investigating whether viruses that have adapted to higher temperatures -- similar to increases due to global warming -- can jump species more easily. ... > full story

Fewer left-sided colorectal tumors observed after colonoscopies (January 2, 2010) -- The prevalence of left-sided advanced colorectal neoplasms was lower in participants in a community setting, but not right-sided advanced neoplams, who had received a colonoscopy in the preceding 10 years, according to a new study. ... > full story

Genomic differences identified in common skin diseases may lead to better treatments (January 2, 2010) -- Scientists have drilled down on the molecular nitty-gritty that distinguishes the two most common forms of inflammatory skin disease, atopic eczema and psoriasis. The researchers say that the ability to distinguish between the disorders' genetic and immunological signatures opens the door for more narrowly targeted therapies sorely needed by the millions of people afflicted worldwide. ... > full story

Bacterial protein mimics its host to disable a key enzyme (January 2, 2010) -- Helicobacter pylori infects up to 90 percent of people in the developing world and causes gastric ulcers and cancers of the gut. Now scientists have revealed a subterfuge used by the bacterium to trick stomach cells into playing along. By injecting a protein into the stomach lining that mimics a native protein but has its opposite effect, the bacterium shuts down a process that helps properly structure stomach tissue, scientists say. ... > full story

It's never too late to quit smoking and save your vision (January 2, 2010) -- Need a little extra incentive to kick the habit? Just in time for New Year's resolutions, a new study finds that even after age 80, smoking continues to increase one's risk for age-related macular degeneration (AMD), the leading cause of blindness in Americans over 65. ... > full story

New research could advance research field critical to personalized medicine (January 1, 2010) -- It's the ultimate goal in the treatment of cancer: tailoring a person's therapy based on his or her genetic makeup. While a lofty goal, scientists are steadily moving forward, rapidly exploiting new technologies. Researchers report a significant advance in this field of research using a new chip that looks for hundreds of mutations in dozen of genes. ... > full story

New molecule identified in DNA damage response (January 1, 2010) -- In the harsh judgment of natural selection, the ultimate measure of success is reproduction. So it's no surprise that life spends lavish resources on this feat, whether in the courtship behavior of birds and bees or replicating the cells that keep them alive. Now research has identified a new piece in an elaborate system to help guarantee fidelity in the reproduction of cells, preventing potentially lethal mutations in the process. ... > full story

The cancer 'TRAP': protein may prevent cancer cell death (January 1, 2010) -- New research suggests that TNF-receptor associated protein-1 (TRAP-1) may prevent cancer cell death. ... > full story

Mutation leads to new and severe form of bacterial disease (January 1, 2010) -- Fighting an illness is not just about fighting the bacteria or viruses that cause it, it also has to do with your genes. Scientists have now identified a gene mutation that makes children susceptible to a severe form of mycobacterial disease, any disease caused by species of Mycobacterium such as tuberculosis and leprosy. The mutation represents a new layer of disease severity in children who lack a vital disease-fighting component from their immune system. ... > full story

Protein link may be key to new treatment for aggressive brain tumor (January 1, 2010) -- Biomedical researchers have found a protein that could hold the key to treating one of the most common and aggressive brain tumors in adults. Glioblastoma multiforme, the type of malignant brain tumor that killed the late US Sen. Edward Kennedy, is difficult to treat because it spreads cancerous cells to other parts of the brain very quickly. About 10,000 cases are diagnosed in the United States each year. ... > full story

New suppressor of common liver cancer (January 1, 2010) -- Tumor suppressor genes make proteins that help control cell growth. Mutations in these genes that generate nonfunctional proteins can contribute to tumor development and progression. One of the most well-known tumor suppressor genes is BRACA1, mutations in which are linked to breast cancer. Researchers have now identified SCARA5 as a candidate tumor suppressor gene in human hepatocellular carcinoma, a form of liver cancer that is the fifth most common cancer worldwide ... > full story

Obesity epidemic taking root in Africa (January 1, 2010) -- The urban poor in sub-Saharan Africa are the latest victims of the obesity epidemic. Researchers claim that overweight and obesity are on the increase among this group. ... > full story

Keeping hepatitis C virus at bay after a liver transplant (January 1, 2010) -- Individuals infected with hepatitis C virus who receive a liver transplant find that their new liver becomes infected with HCV almost immediately. However, researcher in Japan have developed an approach that transiently keeps HCV levels down in most treated HCV-infected patients receiving a new liver. ... > full story

Biofilms: Researchers discover new ways to treat chronic infections (January 1, 2010) -- Researchers have identified three key regulators required for the formation and development of biofilms. The discovery could lead to new ways of treating chronic infections. ... > full story

Genetic link to heart failure (January 1, 2010) -- New research has identified a group of 12 genetic variants in the HSPB7 gene that is associated with heart failure in humans. ... > full story

Influenza in Africa should not be ignored, researchers urge (January 1, 2010) -- Influenza is circulating in Africa, but virtually no information or attention is evident, according to a new article. ... > full story

A facial expression is worth a thousand words (December 31, 2009) -- Moving pictures are more suitable to interpret the mood of a person than a static photograph. Communication is a central aspect of everyday life, a fact that is reflected in the wide variety of ways that people exchange information, not only with words, but also using their face and body. Scientists have now found out that we are able to recognize facial expressions in motion far better than in a static photograph. The video sequence needs to be at least as long as one tenth of a second to gain this dynamic advantage. ... > full story

NEDD9 Protein Supports Growth Of Aggressive Breast Cancer (December 31, 2009) -- Researchers have demonstrated that a protein called NEDD9 may be required for some of the most aggressive forms of breast cancer to grow. According to the researchers, the protein could serve as a clinical biomarker to indicate the presence of aggressive forms of breast cancer. NEDD9 may also provide a target for some future therapeutic against metastatic cancer. ... > full story

Drunk walking makes New Year's the deadliest day of the year for pedestrians (December 31, 2009) -- This is the time of the holiday season when New Year's partiers are inundated with warnings about the risks of drinking and driving. Little is ever heard, though, about the risks of drinking and walking, which can be just as dangerous. ... > full story

New Function For The Protein Bcl-xL: It Prevents Bone Breakdown (December 31, 2009) -- In blood cells, the protein Bcl-xL has a well-characterized role in preventing cell death by a process known as apoptosis. New research has now identified its functions in osteoclasts, cells that slowly breakdown bone (a process known as resorption). Surprisingly, not only does Bcl-xL prevent osteoclast apoptosis in mice, it also negatively regulates the bone-resorbing activity of osteoclasts. ... > full story


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